Science Behind Our Serum

Each ingredient isn’t just hype – there’s solid science and clinical studies supporting its effectiveness:

Redensyl: In clinical trials on men with androgenetic alopecia, 85% of participants had significant, visible hair growth in under 3 months with Redensyl. They experienced a 9% increase in hairs in the growth phase and a 17% decrease in hairs in the falling phase. To put that in perspective, this translated to up to 28,200 new hairs in 84 days for some users – a remarkable result. Notably, Redensyl’s performance has outshined minoxidil in studies, promoting over 90% more hair growth than minoxidil with no known side effects. It’s the first hair growth ingredient developed from regenerative medicine research, targeting hair stem cells to jump-start growth at the cellular level.
AnaGain (Pea Sprout Extract): A clinical study involving AnaGain showed it can improve the ratio of active (anagen) hair follicles to resting (telogen) ones dramatically. Over 3 months, the anagen:telogen ratio went from 4:1 to 7.2:1 – roughly a 78% increase in favor of growing hairs. This means previously dormant follicles started growing hair again, leading to visibly fuller, thicker hair. Another trial (10 volunteers) using 2% pea sprout extract notedenhanced expression of hair-growth genes (FGF7 and noggin) by 56–85% and significantly reduced shedding within 1 month. In short, AnaGain helps reactivate hair growth signals and slow down hair loss, with studies confirming less hair fall after just 1 month and new growth visible by 3 months.
Copper Peptides: Scientific research on copper tripeptides has found they are powerful hair growth promoters with minimal side effects (especially compared to drugs like minoxidil). In lab and animal studies, copper peptides prolong the anagen phase of hair and increase follicle size. For example, one study observed that a copper peptide (AHK-Cu) stimulated human hair follicles to grow by boosting dermal papilla cell activity. Dermatologists note that copper peptides help form new blood capillaries in the scalp, improving oxygen and nutrient delivery to hair roots. They also found that copper peptides lengthened the hair growth phase and shortened the resting phase, leading to less shedding. Even wound-healing studies saw that hair follicles near copper-peptide treated areas grew larger and more robust. All this evidence translates to: copper peptides create a richer scalp environment for hair to grow thicker, stronger, and more plentiful.
Darkenyl: Darkenyl has been clinically proven to repigment grey hair in human trials. In a 4-month double-blind study on people with 30–95% grey hair, those using Darkenyl had over 3× less white hair compared to placebo. In fact, Darkenyl achieved up to a -56% reduction in white hair density on the scalp after 4 months. It works by combining an antioxidant (taxifolin glucoside) that protects and reactivates melanocyte stem cells, with a melanin precursor (N-acetyl-tyrosine) to boost pigment production. The result is that new hair grows in with more of your natural color (Melanogenesis up by 384%), and many users see some of their grey hairs gradually darken (instead of new ones coming in grey). Importantly, this effect is long-lasting and works for all genders and ages – indicating Darkenyl truly addresses the root causes of greying rather than just covering it up.
Greyverse: Greyverse is another novel anti-greying ingredient, and its efficacy is supported by studies as well. Greyverse contains a biomimetic peptide that mimics α-MSH (alpha-Melanocyte Stimulating Hormone), essentially signaling hair follicles to produce more melanin. In clinical use, a topical 2% Greyverse solution preserved the function of melanocytes (hair pigment cells) and promoted natural hair coloring, thereby slowing down the greying process. One company-funded study on premature grey hair showed that Greyverse helps restore natural hair color and reduces the density of grey hairs (participants saw noticeable darkening of individual grey strands). By stimulating the MC1R receptors in follicles, Greyverse encourages even already-greying hairs to grow in darker. The bottom line: Greyverse has science-backed cred, helping turn back the clock on greying hair so new growth is richer in color.
Niacinamide (Vitamin B3): Niacinamide has quietly impressive research behind it for hair health. A 2021 study on human scalp cells found that niacinamide protects hair follicles from premature aging and stress. It was shown to down-regulate DKK-1, a protein that triggers follicle shrinkage and catagen (resting phase) entry, and it reduced markers of cell senescence in hair follicle cells. In simple terms, niacinamide kept the hair papilla cells “young” and active. The researchers concluded that niacinamide can enhance hair growth by preventing oxidative stress-induced follicle aging and keeping hairs in the growth phase longer. Additionally, niacinamide is known to improve scalp conditions: it can increase keratin production and improve the epidermal barrier, which means a healthier scalp that’s more conducive to hair growth. While niacinamide might not be as famous as minoxidil, these studies show it plays a supportive role in reducing hair fall and boosting growth by nurturing the scalp environment and follicle vitality.
Vitamin E (Tocopherol/Tocotrienols): As an antioxidant, Vitamin E’s impact on hair was highlighted in a notable trial. In a 2010 randomized study, volunteers with hair loss took tocotrienol (a form of Vitamin E) supplements for 8 months, and nearly all of them saw an increase in hair count. On average, the Vitamin E group experienced about a 34% increase in the number of hairs on their scalp, whereas the placebo group saw a slight decrease. This improvement is attributed to Vitamin E’s ability to reduce oxidative stress in the scalp – the study noted that lipid peroxidation on the scalp (which can damage hair follicles) was significantly lowered. Topically, Vitamin E in a serum will similarly help by neutralizing free radicals on the scalp. Another effect of vitamin E is improved blood circulation in the skin, which can create a healthier environment for follicles. So, the science suggests Vitamin E protects the scalp and follicles so well that hair can grow in thicker and more plentifully than it would under oxidative attack. It’s especially helpful for people experiencing hair thinning related to stress, pollution, or poor scalp microcirculation.
Pro-Vitamin B5 (Panthenol): Panthenol is a humectant and hair conditioner, and while its benefits are more cosmetic, there is science to back them. Experts note that panthenol penetrates the hair cortex and improves hair elasticity. A well-known effect is that panthenol swells the hair shaft slightly with moisture, making each strand appear thicker (plumping effect). One study on a caffeine + panthenol topical showed that this combo could improve the appearance of thinning hair in women by increasing hair diameter and reinforcement. Additionally, panthenol has an anti-inflammatory effect on the scalp (as it converts to vitamin B5, which is anti-inflammatory), which can soothe irritation that might otherwise hinder optimal hair growth. Several haircare studies and reviews conclude that panthenol helps retain moisture in hair, reduces split ends, and improves shine and softness, all of which contribute to hair that not only looks fuller but is less likely to break off. So while panthenol is not a “growth stimulant” per se, it makes existing hair stronger and thicker – which means you keep the hair you have (reducing breakage/shedding) and it looks more voluminous.
Biotin (Vitamin B7): Biotin’s role in hair is well-established: it’s essential for keratin production. Severe biotin deficiency is known to cause hair loss, and conversely, correcting that deficiency reverses the hair loss. Most people aren’t deficient, but there is anecdotal and some scientific support that extra biotin can improve hair thickness and strength in those who have fine or thinning hair. One peer-reviewed pilot study (on a marine protein supplement with biotin) found significant increases in hair diameter and density in women with thinning hair after 90 days, versus placebo. Biotin was a key component of that supplement, presumably aiding keratin infrastructure. Topically, biotin is often included for its strengthening effect – it’s a small molecule that can to some degree penetrate the hair shaft. While the direct clinical evidence for topical biotin alone is not as robust as some others, its inclusion is considered supportive for overall hair quality. Given that biotin is safe and water-soluble, many dermatologists see it as a helpful addition: ensuring no biotin shortage in the follicle so it can churn out healthy, well-keratinized hair strands. In summary, biotin makes sure the “bricks and mortar” of your hair (keratin proteins) are in ample supply, leading to stronger, more resilient hair growth.
L-Arginine: Arginine has emerging evidence as a hair booster thanks to its effect on nitric oxide (NO) production. NO widens blood vessels (vasodilation), and when arginine is applied to the scalp, it increases localized blood flow. A better blood supply to hair roots means more nutrients and oxygen reach the follicles, which can prolong their growth phase. A study on an arginine-silicate complex showed it could prolong anagen and increase hair density through growth factor stimulation. Moreover, experts from hair clinics note that arginine binds water in the hair shaft, improving hair’s moisture content and elasticity. This reduces brittleness – an arginine-conditioned hair is less likely to snap or shed prematurely. According to HairMD Clinic, arginine (especially as Arginine HCL) “has proven to be very effective in promoting hair growth” by releasing nitric oxide, opening up potassium channels, and nourishing the roots. Their conclusion is that arginine “promotes hair growth by improving blood circulation to the scalp and nourishing hair follicles”, helping reduce damage and breakage. So scientifically, arginine supports hair growth indirectly but powerfully – it creates optimal growth conditions. Think of it as improving the “soil” that your hair grows in (the scalp blood supply), leading to healthier, faster-growing hair.
Saw Palmetto: Saw palmetto’s efficacy in combating hair loss is backed by multiple studies and even systematic reviews. Saw palmetto extract (oral or topical) acts as a natural 5-α-reductase inhibitor, meaning it reduces the conversion of testosterone to DHT – the hormone heavily implicated in androgenetic alopecia. In one clinical trial with 100 men, 38% of those who took saw palmetto saw an improvement in hair growth. Saw palmetto showed a notable benefit with far fewer side effects. Another study using a topical saw palmetto hair tonic found that almost half the participants increased their hair count by ~12% in 4 months. Even more impressively, a systematic review in 2020 summarized that across five RCTs and two cohort studies, saw palmetto yielded “60% improvement in overall hair quality, 27% improvement in total hair count, increased hair density in 83.3% of patients, and stabilized hair loss progression in 52%” of cases. And it did so with no serious adverse effects noted. These numbers underline that saw palmetto – especially in a supportive topical formulation – can significantly slow hair loss and promote modest regrowth. It’s essentially a gentler, natural alternative to drug therapy for hair loss, backed by human trials showing real improvements in density and coverage.
Rosemary Oil: Rosemary essential oil has perhaps some of the most compelling clinical evidence among herbs for hair growth. A 2015 randomized controlled trial pitted rosemary oil against 2% minoxidil in 100 patients with androgenetic alopecia. The results: after 6 months, both groups saw a significant increase in hair count, and rosemary oil’s improvement was on par with minoxidil. There was no statistically significant difference in hair count between rosemary and minoxidil at 6 months – indicating rosemary worked just as well as the gold-standard drug in this study. Importantly, the rosemary group had less scalp itching and side effects than the minoxidil group. Beyond this headline study, rosemary’s benefit comes from its ability to increase microcapillary perfusion (blood flow) in the scalp and its anti-DHT properties (carnosic acid in rosemary can inhibit DHT formation in hair follicles, according to some research). Additionally, rosemary oil has anti-microbial and anti-inflammatory effects, which can help with scalp conditions that stunt hair growth. Summarizing the science: rosemary oil is a proven natural hair growth stimulant – one study literally showed it can match minoxidil’s efficacy – making it a fantastic ingredient for those seeking results without harsh chemicals.
Green Tea (EGCG): The polyphenols in green tea, especially EGCG (Epigallocatechin-3-gallate), have shown promising hair growth effects in research. EGCG is known to inhibit 5-alpha-reductase, thereby reducing DHT levels around hair follicles. A landmark 2007 study by Korean researchers demonstrated that EGCG stimulates human hair growth: they found it promoted hair follicle elongation in organ culture and proliferated dermal papilla cells (the key drivers of hair growth) by activating growth pathways (Erk/Akt) and anti-apoptotic signals. In layman’s terms, EGCG kept hair follicles alive and growing when they otherwise might be shrinking. Moreover, an in vivo mouse study showed significantly less hair loss in rodents treated with topical green tea extract, as EGCG extended their hair’s anagen phase. For humans, a small study applied EGCG-rich topical solution to the scalps of volunteers with alopecia; after just 4 days, researchers observed significant increases in markers of hair growth activity in the scalp biopsies. The Healthline review of this topic concludes that EGCG prolongs the growth phase and slows the shedding phase, likely by countering testosterone/DHT’s hair-fall effects. So green tea extract in this serum is not just a feel-good addition – it’s actively protecting follicles and promoting new growth, with antioxidant power that also keeps the scalp healthier.
Caffeine: Caffeine’s ability to stimulate hair growth is well documented in lab studies and has even seen success in clinical settings (particularly for female pattern hair loss). A notable laboratory study published in 2007 found that caffeine counteracts the suppressive effects of DHT on hair follicles. It stimulated hair shaft elongation and prolonged the anagen (growth) duration in male hair follicles in vitro. In fact, hair follicles treated with caffeine showed longer and wider roots than untreated ones. The same study also tested female follicles and found caffeine had a growth-promoting effect on them as well. The mechanism is thought to be caffeine’s role as a phosphodiesterase inhibitor, which increases cellular energy (cAMP) in the follicle cells, somewhat like “giving them a jolt”. Clinically, a 2018 study found that a caffeine-based topical liquid was as effective as minoxidil 5% in women with diffuse hair loss after 6 months, in terms of improving hair density. Dermatologists often cite caffeine as useful because it increases blood circulation in the scalp (as a stimulant) and can quickly penetrate hair follicles. So the evidence boils down to: caffeine wakes up hair roots and helps them grow faster and keep growing. It’s an ideal ingredient to pair with DHT blockers because caffeine both protects follicles from DHT and directly encourages growth. For the user, this means potentially seeing faster results – some in vitro data showed hair follicles exposed to caffeine had a spurt in growth output in as little as 7-8 days.
Hyaluronic Acid: While hyaluronic acid (HA) is included primarily for hydration and scalp comfort, this indirectly contributes to better hair growth, and here’s how: A well-hydrated scalp has improved blood circulation and elasticity, making it easier for new hairs to push through. Dr. Beth Goldstein (board-certified dermatologist) explains that hyaluronic acid can hold immense amounts of water and “adds moisture to hair follicles, providing a smoother, less frizzy appearance”. If hair is lacking moisture, it can become dry and prone to breakage; HA steps in to boost hair’s ability to hold onto moisture. There’s also evidence that HA can soothe the scalp – a healthy, irritation-free scalp tends to have stronger hair growth. In fact, some hair transplant clinics use topical HA post-surgery to speed healing and improve follicle survival. By revitalizing the scalp and conditioning the hair strand, hyaluronic acid ensures that all the growth-boosting actives (above) can work in an optimal environment. Think of it as keeping the “ground” fertile and flexible for the new “plants” (hairs) to come through. One can especially notice HA’s benefit in reduced hair breakage – hydrated hair bends instead of snaps. So, while HA itself isn’t making hair sprout, it’s supporting the overall efficacy of the serum: hair that grows is well-moisturized, appears thicker (plump with water), and has a healthy shine and texture. This is why even though it’s a care ingredient, we highlight it – because great hair growth also depends on great hair health, and HA delivers on that front.